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Dihexa: the neurotrophic giant from angiotensin IV Origin and structure Dihexa (N-hexanoic-Tyr-Ile-(6) amino-hexanoic-amide, also called PNB-0408) is a modified analogue of angiotensin IV (Ang IV: Val-Tyr-Ile-His-Pro-Phe), developed in Joseph Harding's laboratory (Washington State University) from 2010-2012

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The copper-bound form (GHK-Cu) has been studied for decades, primarily by Pickart and colleagues, and its safety profile has been described as benign at research and compounded doses across multiple review papers